early career scientist
Rebekah Honce, PhD
virologist that dabbles in immunology and ecology
A little about me
My research focuses on the dynamic interactions between hosts and viruses, particularly at the animal-human interface. I am interested in how viral diversity influences infection outcomes and how host factors shape pathogenesis and transmission of zoonotic infections. My long-term goal is to explore how viruses reprogram host metabolism to persist in reservoir and to infect spillover hosts.
Research
I'm currently working with Jason Botten, PhD on arenavirus pathogenesis and cellular virology
Now more than ever, we must identify the viral and host determinants of spillover from animal reservoirs to human hosts. Through my graduate studies, I questioned how host status can inform influenza virus and coronavirus pathogenesis. This included studies on transmission bottlenecks between hosts and susceptibility to infection as well as investigation into host immune responses and vaccine efficacy.
As a postdoc, I am continuing my investigation into host-viral interactions by investigating the role of defective interfering particles in mammarenavirus pathogenesis and persistence in reservoir host, and how we could exploit these as therapeutics. I am dipping my toes into disease ecology as well as molecular and cellular virology to uncover the cellular and viral factors implicated in these varying disease outcomes.
I have an expertise in RNA viral biology and modeling viral disease pathogenesis in vitro and in small and large animal models. My background in host factors that influence susceptibility to viral infection pairs nicely with my current focus on identifying viral factors affecting human disease. I aim to continue exploring viruses at the animal-human interface, including understanding the metabolic and immunologic mechanisms that favor viral maintenance in animal reservoirs and factors that favor transmission.
Skills and Training
I'm an RNA virus enthusiast who works across biological scales to answer my research questions
Models of RNA virus biology
Including mouse, ferret, hamster, and avian models of infection and transmission and molecular, cellular, serologic and biochemical assays.
ABSL-3 Proficiency
Over 1,000 hours logged including in vivo infection and transmission models and standard virologic assays using multiple viral pathogens of pandemic potential.
Constant work-in-progress
Committed to increasing research equity, rigor, and reproducibility by seeking out trainings in inclusivity, biosafety, statistics, and data visualization.
CV At-a-Glance
Check out my virtual CV or download the PDF for more information on my approach to research, teaching, service, and outreach
Education
I am a proud alumnus of West Virginia Wesleyan College '16 and hold a PhD in Biomedical Sciences from University of Tennessee HSC '20. I am currently expanding postdoctoral scientist at UVM.
Research
Using complementary in vivo and in vitro approaches, I tease apart cellular and viral factors involved in disease to uncover the secrets of RNA virus pathogenesis across multiple biological scales.
Teaching
Through thoughtful course development, I have developed an empathetic education style to facilitate a life-long love of learning in students with two main tenets: information literacy and connecting science with society.
Service
I work to make science more accessible by advancing equity in academic research, increase scientific literacy through creative public communication and improve the graduate student and postdoctoral experience.
Recent Publications
Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice
Honce R*, Vazquez-Pagan A*, Livingston B, Mandarano AH, Wilander BA, Cherry S, Hargest V, Sharp B, Prigleb PH, Kirkpatrick Roubidoux E, Van de Velde LA, Skinner RC, McGargill MA, Thomas PG, Schultz-Cherry S.
Nature Microbiology. 18 April 2024. doi: 10.1038/s41564-024-01677-y
Diet-induced obesity impacts influenza disease severity and transmission dynamics in ferrets
Meliopoulos V*, Honce R*, Livingston B, Hargest G, Frieden P, Lazure L, Brigleb P, Karlsson EA, Tillman H, Allen EK, Boyd D, Thomas P, Schultz-Cherry S.
Science Advances. 8 April 2024. doi: 10.1126/sciadv.adk9137
Looking beyond the H5 avian influenza viruses
Honce R and Schultz-Cherry S.
Cell. 14 September 2023. doi: 10.1016/j.cell.2023.08.014
Influenza defective interfering virus promotes multifaceted cell differentiation and reduces the inflammatory response in mice
Wang C, Honce R, Salvatore M, Chow D, Randazzo D, Yang J, Twells NM, Mahal LK, Schultz-Cherry S, Ghedin E.
Journal of Virology. 31 May 2023. doi: 10.1128/jvi.00493-23
Beyond the Laboratory
Bucket-list Concerts
As an avid music lover with no discernible music talent, I'm excited to cross off some bucket-list artists in 2024. After Bruce Springsteen this Spring, we're headed to Boston in November for Johnny Blue Skies aka Sturgill Simpson.
A Link to the Past
My husband got me into video games beyond the Super Mario Bros. series of my childhood during the "COVID Times." After my second play-through of Skyrim, we finally bit the bullet and dove into BOTW and TOTK. Now, I'm tackling the Legend of Zelda and Fallout series.
Green Mountain Summits
On a mission to summit the local peaks. We have crossed off Mt. Mansfield, Camel's Hump, Sterling Pond, and Mt. Philo, the latter with our pup in tow, and next up is Mt. Abe. We're hoping to traverse the White Mountains of New Hampshire in 2025!
